Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques

Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.

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Autores principales: Benjamin J. Burwitz, Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, Mina Northrup, Benjamin N. Bimber, Thomas Jacob, Jason S. Reed, Reed Norris, Byung Park, Sven Moller-Tank, Knud Esser, Justin M. Greene, Helen L. Wu, Shaheed Abdulhaqq, Gabriela Webb, William F. Sutton, Alex Klug, Tonya Swanson, Alfred W. Legasse, Tania Q. Vu, Aravind Asokan, Nancy L. Haigwood, Ulrike Protzer, Jonah B. Sacha
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a
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https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a

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