Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.
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Nature Portfolio
2017
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oai:doaj.org-article:2039d96647514d3c9a3deb587404ab5a2021-12-02T14:42:34ZHepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques10.1038/s41467-017-01953-y2041-1723https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01953-yhttps://doaj.org/toc/2041-1723Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies.Benjamin J. BurwitzJochen M. WettengelMartin A. Mück-HäuslMarc RingelhanChunkyu KoMarvin M. FestagKatherine B. HammondMina NorthrupBenjamin N. BimberThomas JacobJason S. ReedReed NorrisByung ParkSven Moller-TankKnud EsserJustin M. GreeneHelen L. WuShaheed AbdulhaqqGabriela WebbWilliam F. SuttonAlex KlugTonya SwansonAlfred W. LegasseTania Q. VuAravind AsokanNancy L. HaigwoodUlrike ProtzerJonah B. SachaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Benjamin J. Burwitz Jochen M. Wettengel Martin A. Mück-Häusl Marc Ringelhan Chunkyu Ko Marvin M. Festag Katherine B. Hammond Mina Northrup Benjamin N. Bimber Thomas Jacob Jason S. Reed Reed Norris Byung Park Sven Moller-Tank Knud Esser Justin M. Greene Helen L. Wu Shaheed Abdulhaqq Gabriela Webb William F. Sutton Alex Klug Tonya Swanson Alfred W. Legasse Tania Q. Vu Aravind Asokan Nancy L. Haigwood Ulrike Protzer Jonah B. Sacha Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques |
| description |
Hepatitis B virus (HBV) has a limited host range and current animal models can only recapitulate certain aspects of HBV replication. Here, the authors show that expression of the HBV receptor NTCP in macaques supports HBV replication in vivo, suggesting this as animal model for future HBV studies. |
| format |
article |
| author |
Benjamin J. Burwitz Jochen M. Wettengel Martin A. Mück-Häusl Marc Ringelhan Chunkyu Ko Marvin M. Festag Katherine B. Hammond Mina Northrup Benjamin N. Bimber Thomas Jacob Jason S. Reed Reed Norris Byung Park Sven Moller-Tank Knud Esser Justin M. Greene Helen L. Wu Shaheed Abdulhaqq Gabriela Webb William F. Sutton Alex Klug Tonya Swanson Alfred W. Legasse Tania Q. Vu Aravind Asokan Nancy L. Haigwood Ulrike Protzer Jonah B. Sacha |
| author_facet |
Benjamin J. Burwitz Jochen M. Wettengel Martin A. Mück-Häusl Marc Ringelhan Chunkyu Ko Marvin M. Festag Katherine B. Hammond Mina Northrup Benjamin N. Bimber Thomas Jacob Jason S. Reed Reed Norris Byung Park Sven Moller-Tank Knud Esser Justin M. Greene Helen L. Wu Shaheed Abdulhaqq Gabriela Webb William F. Sutton Alex Klug Tonya Swanson Alfred W. Legasse Tania Q. Vu Aravind Asokan Nancy L. Haigwood Ulrike Protzer Jonah B. Sacha |
| author_sort |
Benjamin J. Burwitz |
| title |
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques |
| title_short |
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques |
| title_full |
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques |
| title_fullStr |
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques |
| title_full_unstemmed |
Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques |
| title_sort |
hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis b virus infection of macaques |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/2039d96647514d3c9a3deb587404ab5a |
| work_keys_str_mv |
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