Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells

Therapeutics delivery by using non-viral vectors presents several challenges in the design of an appropriate polymeric structure. Here, the authors report a series of highly branched, biodegradable polymers which show high transfection efficiency in human multipotent adipose derived stem cells and p...

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Autores principales:	Shuai Liu, Yongsheng Gao, Dezhong Zhou, Ming Zeng, Fatma Alshehri, Ben Newland, Jing Lyu, Jonathan O’Keeffe-Ahern, Udo Greiser, Tianying Guo, Fengzhi Zhang, Wenxin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2041b53257aa4eca91450efc3f037e8c
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spelling	oai:doaj.org-article:2041b53257aa4eca91450efc3f037e8c2021-12-02T17:01:52ZHighly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells10.1038/s41467-019-11190-02041-1723https://doaj.org/article/2041b53257aa4eca91450efc3f037e8c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11190-0https://doaj.org/toc/2041-1723Therapeutics delivery by using non-viral vectors presents several challenges in the design of an appropriate polymeric structure. Here, the authors report a series of highly branched, biodegradable polymers which show high transfection efficiency in human multipotent adipose derived stem cells and primary astrocytes.Shuai LiuYongsheng GaoDezhong ZhouMing ZengFatma AlshehriBen NewlandJing LyuJonathan O’Keeffe-AhernUdo GreiserTianying GuoFengzhi ZhangWenxin WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuai Liu Yongsheng Gao Dezhong Zhou Ming Zeng Fatma Alshehri Ben Newland Jing Lyu Jonathan O’Keeffe-Ahern Udo Greiser Tianying Guo Fengzhi Zhang Wenxin Wang Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
description	Therapeutics delivery by using non-viral vectors presents several challenges in the design of an appropriate polymeric structure. Here, the authors report a series of highly branched, biodegradable polymers which show high transfection efficiency in human multipotent adipose derived stem cells and primary astrocytes.
format	article
author	Shuai Liu Yongsheng Gao Dezhong Zhou Ming Zeng Fatma Alshehri Ben Newland Jing Lyu Jonathan O’Keeffe-Ahern Udo Greiser Tianying Guo Fengzhi Zhang Wenxin Wang
author_facet	Shuai Liu Yongsheng Gao Dezhong Zhou Ming Zeng Fatma Alshehri Ben Newland Jing Lyu Jonathan O’Keeffe-Ahern Udo Greiser Tianying Guo Fengzhi Zhang Wenxin Wang
author_sort	Shuai Liu
title	Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
title_short	Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
title_full	Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
title_fullStr	Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
title_full_unstemmed	Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells
title_sort	highly branched poly(β-amino ester) delivery of minicircle dna for transfection of neurodegenerative disease related cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2041b53257aa4eca91450efc3f037e8c
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Highly branched poly(β-amino ester) delivery of minicircle DNA for transfection of neurodegenerative disease related cells

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