Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer’s disease

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia and behavioral changes. Extracellular deposition of amyloid plaques (Aβ) and intracellular deposition of neurofibrillary tangles in neurons are the major pathogenicities of AD. However, drugs ta...

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Auteurs principaux: Renuka Prasad, Hwajin Jung, Anderson Tan, Yonghee Song, Sungho Moon, Mohammed R. Shaker, Woong Sun, Junghee Lee, Hoon Ryu, Hyun Kook Lim, Eek-hoon Jho
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/2059ccfe55644e8bae90c637012f62df
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