MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation

MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation

ABSTRACT Membrane-associated RING-CH-type 8 (MARCH8) strongly blocks human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) incorporation into virions by downregulating its cell surface expression, but the mechanism is still unclear. We now report that MARCH8 also blocks the Ebola v...

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Autores principales: Changqing Yu, Sunan Li, Xianfeng Zhang, Ilyas Khan, Iqbal Ahmad, Yulong Zhou, Shuo Li, Jing Shi, Yu Wang, Yong-Hui Zheng
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Ebola
HIV
MARCH8
class I fusion protein
furin
glycosylation
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/2072e260d8684d80bb2cee0ec0199e67
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https://doaj.org/article/2072e260d8684d80bb2cee0ec0199e67

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