Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice

Mice are a widely used pre-clinical model system in large part due to their potential for genetic manipulation. The ability to manipulate gene expression in specific cells under temporal control is a powerful experimental tool. The liver is central to metabolic homeostasis and a site of many disease...

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Autores principales: Christos Kiourtis, Ania Wilczynska, Colin Nixon, William Clark, Stephanie May, Thomas G. Bird
Formato: article
Lenguaje:EN
Publicado: The Company of Biologists 2021
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Acceso en línea:https://doaj.org/article/20782b67b1f6464d846e370308cf1da4
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