Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Parkinson’s disease (PD) is caused by progressive neurodegeneration and characterised by motor dysfunction. Neurodegeneration of dopaminergic neurons also causes aberrations within the cortico-striato-thalamo-cortical (CSTC) circuit, which has been hypothesised to lead to non-motor symptoms such as...

Full description

Saved in:
Bibliographic Details
Main Authors: Nakul Ravi Raval, Frederik Gudmundsen, Morten Juhl, Ida Vang Andersen, Nikolaj Speth, Annesofie Videbæk, Ida Nymann Petersen, Jens D. Mikkelsen, Patrick MacDonald Fisher, Matthias Manfred Herth, Pontus Plavén-Sigray, Gitte Moos Knudsen, Mikael Palner
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
Parkinson’s disease (PD)
dopamine neurodegeneration
6-OHDA = 6-hydroxydopamine
CSTC = cortico-striato-thalamo-cortical
FDG – PET
SV2A
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Online Access:https://doaj.org/article/208306ca073a449cbd98aebf8b4617c7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/208306ca073a449cbd98aebf8b4617c7

Similar Items