Quantitative analysis of 3D alignment quality: its impact on soft-validation, particle pruning and homogeneity analysis

Abstract Single Particle Analysis using cryo-electron microscopy is a structural biology technique aimed at capturing the three-dimensional (3D) conformation of biological macromolecules. Projection images used to construct the 3D density map are characterized by a very low signal-to-noise ratio to...

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Autores principales: J. Vargas, R. Melero, J. Gómez-Blanco, J. M. Carazo, C. O. S. Sorzano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/208ac4f5b9214c67b19c4936d2209615
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