New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas

Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel quid usage, alcohol consumption, and HPV infec...

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Main Authors:	Cristina Porcheri, Thimios A. Mitsiadis
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	head and neck squamous cell carcinoma oral cancer drug testing drug delivery organoids spheroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Online Access:	https://doaj.org/article/20cdbf784bbd421bbf3b0fa1bee49e72
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id	oai:doaj.org-article:20cdbf784bbd421bbf3b0fa1bee49e72
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spelling	oai:doaj.org-article:20cdbf784bbd421bbf3b0fa1bee49e722021-11-11T15:33:49ZNew Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas10.3390/cancers132155152072-6694https://doaj.org/article/20cdbf784bbd421bbf3b0fa1bee49e722021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5515https://doaj.org/toc/2072-6694Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel quid usage, alcohol consumption, and HPV infection. Oral squamous cell carcinoma, as other head and neck cancers, presents a high degree of intratumor heterogeneity, which makes their treatment difficult, and directly correlates with drug resistance. Since the classical treatments for HNSCC oftentimes do not resolve the clinical picture, there is great need for novel therapeutic approaches, models for drug testing, and new drug delivery systems.Cristina PorcheriThimios A. MitsiadisMDPI AGarticlehead and neck squamous cell carcinomaoral cancerdrug testingdrug deliveryorganoidsspheroidsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5515, p 5515 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck squamous cell carcinoma oral cancer drug testing drug delivery organoids spheroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	head and neck squamous cell carcinoma oral cancer drug testing drug delivery organoids spheroids Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cristina Porcheri Thimios A. Mitsiadis New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
description	Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent types of cancer with a lethal outcome in half of the diagnosed cases. Mostly, HNSCC develops in the oral cavity, and its development is associated with tobacco and areca nut/betel quid usage, alcohol consumption, and HPV infection. Oral squamous cell carcinoma, as other head and neck cancers, presents a high degree of intratumor heterogeneity, which makes their treatment difficult, and directly correlates with drug resistance. Since the classical treatments for HNSCC oftentimes do not resolve the clinical picture, there is great need for novel therapeutic approaches, models for drug testing, and new drug delivery systems.
format	article
author	Cristina Porcheri Thimios A. Mitsiadis
author_facet	Cristina Porcheri Thimios A. Mitsiadis
author_sort	Cristina Porcheri
title	New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
title_short	New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
title_full	New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
title_fullStr	New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
title_full_unstemmed	New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
title_sort	new scenarios in pharmacological treatments of head and neck squamous cell carcinomas
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/20cdbf784bbd421bbf3b0fa1bee49e72
work_keys_str_mv	AT cristinaporcheri newscenariosinpharmacologicaltreatmentsofheadandnecksquamouscellcarcinomas AT thimiosamitsiadis newscenariosinpharmacologicaltreatmentsofheadandnecksquamouscellcarcinomas
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New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas

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