Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging in animals.
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Nature Portfolio
2017
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oai:doaj.org-article:212be03b3e8048e28651330ac60c124f2021-12-02T13:57:55ZEvery-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice10.1038/s41467-017-00178-32041-1723https://doaj.org/article/212be03b3e8048e28651330ac60c124f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00178-3https://doaj.org/toc/2041-1723Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging in animals.Kan XieFrauke NeffAstrid MarkertJan RozmanJuan Antonio Aguilar-PimentelOana Veronica AmarieLore BeckerRobert BrommageLillian GarrettKristin S. HenzelSabine M. HölterDirk JanikIsabelle LehmannKristin MorethBrandon L. PearsonIldiko RaczBirgit RathkolbDevon P. RyanSusanne SchröderIrina TreiseRaffi BekeredjianDirk H. BuschJochen GrawGerhard EhningerMartin KlingensporThomas KlopstockMarkus OllertMichael SandholzerCarsten Schmidt-WeberMarco WeiergräberEckhard WolfWolfgang WurstAndreas ZimmerValerie Gailus-DurnerHelmut FuchsMartin Hrabě de AngelisDan EhningerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017) |
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| collection |
DOAJ |
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EN |
| topic |
Science Q |
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Science Q Kan Xie Frauke Neff Astrid Markert Jan Rozman Juan Antonio Aguilar-Pimentel Oana Veronica Amarie Lore Becker Robert Brommage Lillian Garrett Kristin S. Henzel Sabine M. Hölter Dirk Janik Isabelle Lehmann Kristin Moreth Brandon L. Pearson Ildiko Racz Birgit Rathkolb Devon P. Ryan Susanne Schröder Irina Treise Raffi Bekeredjian Dirk H. Busch Jochen Graw Gerhard Ehninger Martin Klingenspor Thomas Klopstock Markus Ollert Michael Sandholzer Carsten Schmidt-Weber Marco Weiergräber Eckhard Wolf Wolfgang Wurst Andreas Zimmer Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Dan Ehninger Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| description |
Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging in animals. |
| format |
article |
| author |
Kan Xie Frauke Neff Astrid Markert Jan Rozman Juan Antonio Aguilar-Pimentel Oana Veronica Amarie Lore Becker Robert Brommage Lillian Garrett Kristin S. Henzel Sabine M. Hölter Dirk Janik Isabelle Lehmann Kristin Moreth Brandon L. Pearson Ildiko Racz Birgit Rathkolb Devon P. Ryan Susanne Schröder Irina Treise Raffi Bekeredjian Dirk H. Busch Jochen Graw Gerhard Ehninger Martin Klingenspor Thomas Klopstock Markus Ollert Michael Sandholzer Carsten Schmidt-Weber Marco Weiergräber Eckhard Wolf Wolfgang Wurst Andreas Zimmer Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Dan Ehninger |
| author_facet |
Kan Xie Frauke Neff Astrid Markert Jan Rozman Juan Antonio Aguilar-Pimentel Oana Veronica Amarie Lore Becker Robert Brommage Lillian Garrett Kristin S. Henzel Sabine M. Hölter Dirk Janik Isabelle Lehmann Kristin Moreth Brandon L. Pearson Ildiko Racz Birgit Rathkolb Devon P. Ryan Susanne Schröder Irina Treise Raffi Bekeredjian Dirk H. Busch Jochen Graw Gerhard Ehninger Martin Klingenspor Thomas Klopstock Markus Ollert Michael Sandholzer Carsten Schmidt-Weber Marco Weiergräber Eckhard Wolf Wolfgang Wurst Andreas Zimmer Valerie Gailus-Durner Helmut Fuchs Martin Hrabě de Angelis Dan Ehninger |
| author_sort |
Kan Xie |
| title |
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| title_short |
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| title_full |
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| title_fullStr |
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| title_full_unstemmed |
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| title_sort |
every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/212be03b3e8048e28651330ac60c124f |
| work_keys_str_mv |
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