Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.

Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.

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Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers. It is still unclear if the assembly of a polym...

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Autores principales: Dennis J Doorduijn, Dani A C Heesterbeek, Maartje Ruyken, Carla J C de Haas, Daphne A C Stapels, Piet C Aerts, Suzan H M Rooijakkers, Bart W Bardoel
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/213580cfed6a4b06a4208b7d41522f83
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https://doaj.org/article/213580cfed6a4b06a4208b7d41522f83

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