Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores.
Complement proteins can form membrane attack complex (MAC) pores that directly kill Gram-negative bacteria. MAC pores assemble by stepwise binding of C5b, C6, C7, C8 and finally C9, which can polymerize into a transmembrane ring of up to 18 C9 monomers. It is still unclear if the assembly of a polym...
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Public Library of Science (PLoS)
2021
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| Acceso en línea: | https://doaj.org/article/213580cfed6a4b06a4208b7d41522f83 |
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por Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel
Publicado 2021
Enlace del recursoPublicado 2021
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