Discovery of New Ginsenol-Like Compounds with High Antiviral Activity

A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which...

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Autores principales:	Aleksandrina S. Volobueva, Olga I. Yarovaya, Marina V. Kireeva, Sophia S. Borisevich, Kseniya S. Kovaleva, Iliya Ya. Mainagashev, Yuri V. Gatilov, Margarita G. Ilyina, Vladimir V. Zarubaev, Nariman F. Salakhutdinov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Ginsenol Ginsamide antiviral agent surface protein influenza resistance Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/213d0b8301074d2988865ebc91dd9b70
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spelling	oai:doaj.org-article:213d0b8301074d2988865ebc91dd9b702021-11-25T18:27:18ZDiscovery of New Ginsenol-Like Compounds with High Antiviral Activity10.3390/molecules262267941420-3049https://doaj.org/article/213d0b8301074d2988865ebc91dd9b702021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6794https://doaj.org/toc/1420-3049A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.Aleksandrina S. VolobuevaOlga I. YarovayaMarina V. KireevaSophia S. BorisevichKseniya S. KovalevaIliya Ya. MainagashevYuri V. GatilovMargarita G. IlyinaVladimir V. ZarubaevNariman F. SalakhutdinovMDPI AGarticleGinsenolGinsamideantiviral agentsurface proteininfluenzaresistanceOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6794, p 6794 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ginsenol Ginsamide antiviral agent surface protein influenza resistance Organic chemistry QD241-441
spellingShingle	Ginsenol Ginsamide antiviral agent surface protein influenza resistance Organic chemistry QD241-441 Aleksandrina S. Volobueva Olga I. Yarovaya Marina V. Kireeva Sophia S. Borisevich Kseniya S. Kovaleva Iliya Ya. Mainagashev Yuri V. Gatilov Margarita G. Ilyina Vladimir V. Zarubaev Nariman F. Salakhutdinov Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
description	A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.
format	article
author	Aleksandrina S. Volobueva Olga I. Yarovaya Marina V. Kireeva Sophia S. Borisevich Kseniya S. Kovaleva Iliya Ya. Mainagashev Yuri V. Gatilov Margarita G. Ilyina Vladimir V. Zarubaev Nariman F. Salakhutdinov
author_facet	Aleksandrina S. Volobueva Olga I. Yarovaya Marina V. Kireeva Sophia S. Borisevich Kseniya S. Kovaleva Iliya Ya. Mainagashev Yuri V. Gatilov Margarita G. Ilyina Vladimir V. Zarubaev Nariman F. Salakhutdinov
author_sort	Aleksandrina S. Volobueva
title	Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_short	Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_full	Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_fullStr	Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_full_unstemmed	Discovery of New Ginsenol-Like Compounds with High Antiviral Activity
title_sort	discovery of new ginsenol-like compounds with high antiviral activity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/213d0b8301074d2988865ebc91dd9b70
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Discovery of New Ginsenol-Like Compounds with High Antiviral Activity

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