Unexpected Mutations in HIV-1 That Confer Resistance to the Tat Inhibitor Didehydro-Cortistatin A
ABSTRACT Didehydro-cortistatin A (dCA) is a human immunodeficiency virus type 1 (HIV-1) Tat inhibitor that functions by selectively binding to the RNA binding domain of Tat. In addition to inhibiting viral replication, dCA can drive HIV-1 into a state of “deep latency” in which latent viruses are re...
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| Format: | article |
| Language: | EN |
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American Society for Microbiology
2019
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| Online Access: | https://doaj.org/article/2155958c270a45ffb27fc1864c1f61ec |
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