Functional disease architectures reveal unique biological role of transposable elements

Transposable elements (TE) make up a large component of the human genome and have been shown to contribute to human diseases. Here, Hormozdiari et al. estimate the contribution of TEs to the heritability of 41 complex traits and diseases and find enrichment of SINEs in blood traits.

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Autores principales:	Farhad Hormozdiari, Bryce van de Geijn, Joseph Nasser, Omer Weissbrod, Steven Gazal, Chelsea J. -T. Ju, Luke O’ Connor, Margaux L. A. Hujoel, Jesse Engreitz, Fereydoun Hormozdiari, Alkes L. Price
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2162e007b86c49c889aa730a2d6a4779
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spelling	oai:doaj.org-article:2162e007b86c49c889aa730a2d6a47792021-12-02T17:02:11ZFunctional disease architectures reveal unique biological role of transposable elements10.1038/s41467-019-11957-52041-1723https://doaj.org/article/2162e007b86c49c889aa730a2d6a47792019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11957-5https://doaj.org/toc/2041-1723Transposable elements (TE) make up a large component of the human genome and have been shown to contribute to human diseases. Here, Hormozdiari et al. estimate the contribution of TEs to the heritability of 41 complex traits and diseases and find enrichment of SINEs in blood traits.Farhad HormozdiariBryce van de GeijnJoseph NasserOmer WeissbrodSteven GazalChelsea J. -T. JuLuke O’ ConnorMargaux L. A. HujoelJesse EngreitzFereydoun HormozdiariAlkes L. PriceNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Farhad Hormozdiari Bryce van de Geijn Joseph Nasser Omer Weissbrod Steven Gazal Chelsea J. -T. Ju Luke O’ Connor Margaux L. A. Hujoel Jesse Engreitz Fereydoun Hormozdiari Alkes L. Price Functional disease architectures reveal unique biological role of transposable elements
description	Transposable elements (TE) make up a large component of the human genome and have been shown to contribute to human diseases. Here, Hormozdiari et al. estimate the contribution of TEs to the heritability of 41 complex traits and diseases and find enrichment of SINEs in blood traits.
format	article
author	Farhad Hormozdiari Bryce van de Geijn Joseph Nasser Omer Weissbrod Steven Gazal Chelsea J. -T. Ju Luke O’ Connor Margaux L. A. Hujoel Jesse Engreitz Fereydoun Hormozdiari Alkes L. Price
author_facet	Farhad Hormozdiari Bryce van de Geijn Joseph Nasser Omer Weissbrod Steven Gazal Chelsea J. -T. Ju Luke O’ Connor Margaux L. A. Hujoel Jesse Engreitz Fereydoun Hormozdiari Alkes L. Price
author_sort	Farhad Hormozdiari
title	Functional disease architectures reveal unique biological role of transposable elements
title_short	Functional disease architectures reveal unique biological role of transposable elements
title_full	Functional disease architectures reveal unique biological role of transposable elements
title_fullStr	Functional disease architectures reveal unique biological role of transposable elements
title_full_unstemmed	Functional disease architectures reveal unique biological role of transposable elements
title_sort	functional disease architectures reveal unique biological role of transposable elements
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2162e007b86c49c889aa730a2d6a4779
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Functional disease architectures reveal unique biological role of transposable elements

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