Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

A membrane-exposed groove in Ca2+-gated TMEM16 scramblases forms the translocation pathway for ions and lipids. Here authors combine molecular dynamics with cryo-EM and functional assays to uncover the conformational transitions of the groove leading to a non-selective ion channel pore.

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Autores principales:	George Khelashvili, Maria E. Falzone, Xiaolu Cheng, Byoung-Cheol Lee, Alessio Accardi, Harel Weinstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/217f3e9521bd47ab84603e12a70c94d1
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spelling	oai:doaj.org-article:217f3e9521bd47ab84603e12a70c94d12021-12-02T16:57:44ZDynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM1610.1038/s41467-019-12865-42041-1723https://doaj.org/article/217f3e9521bd47ab84603e12a70c94d12019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12865-4https://doaj.org/toc/2041-1723A membrane-exposed groove in Ca2+-gated TMEM16 scramblases forms the translocation pathway for ions and lipids. Here authors combine molecular dynamics with cryo-EM and functional assays to uncover the conformational transitions of the groove leading to a non-selective ion channel pore.George KhelashviliMaria E. FalzoneXiaolu ChengByoung-Cheol LeeAlessio AccardiHarel WeinsteinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q George Khelashvili Maria E. Falzone Xiaolu Cheng Byoung-Cheol Lee Alessio Accardi Harel Weinstein Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
description	A membrane-exposed groove in Ca2+-gated TMEM16 scramblases forms the translocation pathway for ions and lipids. Here authors combine molecular dynamics with cryo-EM and functional assays to uncover the conformational transitions of the groove leading to a non-selective ion channel pore.
format	article
author	George Khelashvili Maria E. Falzone Xiaolu Cheng Byoung-Cheol Lee Alessio Accardi Harel Weinstein
author_facet	George Khelashvili Maria E. Falzone Xiaolu Cheng Byoung-Cheol Lee Alessio Accardi Harel Weinstein
author_sort	George Khelashvili
title	Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
title_short	Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
title_full	Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
title_fullStr	Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
title_full_unstemmed	Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16
title_sort	dynamic modulation of the lipid translocation groove generates a conductive ion channel in ca2+-bound nhtmem16
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/217f3e9521bd47ab84603e12a70c94d1
work_keys_str_mv	AT georgekhelashvili dynamicmodulationofthelipidtranslocationgroovegeneratesaconductiveionchannelinca2boundnhtmem16 AT mariaefalzone dynamicmodulationofthelipidtranslocationgroovegeneratesaconductiveionchannelinca2boundnhtmem16 AT xiaolucheng dynamicmodulationofthelipidtranslocationgroovegeneratesaconductiveionchannelinca2boundnhtmem16 AT byoungcheollee dynamicmodulationofthelipidtranslocationgroovegeneratesaconductiveionchannelinca2boundnhtmem16 AT alessioaccardi dynamicmodulationofthelipidtranslocationgroovegeneratesaconductiveionchannelinca2boundnhtmem16 AT harelweinstein dynamicmodulationofthelipidtranslocationgroovegeneratesaconductiveionchannelinca2boundnhtmem16
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Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

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