Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties.

por Jufang Shan, George Khelashvili, Sayan Mondal, Ernest L Mehler, Harel Weinstein
Publicado 2012

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

por George Khelashvili, Maria E. Falzone, Xiaolu Cheng, Byoung-Cheol Lee, Alessio Accardi, Harel Weinstein
Publicado 2019

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

por Byoung-Cheol Lee, George Khelashvili, Maria Falzone, Anant K. Menon, Harel Weinstein, Alessio Accardi
Publicado 2018

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

por Daniel S. Terry, Rachel A. Kolster, Matthias Quick, Michael V. LeVine, George Khelashvili, Zhou Zhou, Harel Weinstein, Jonathan A. Javitch, Scott C. Blanchard
Publicado 2018

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

por George Khelashvili, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, Tylor R. Lewis, Vadim Y. Arshavsky, Johannes Broichhagen, Joshua Levitz, Anant K. Menon
Publicado 2021

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

por Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Publicado 2020