Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaust...

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Autores principales:	David H. Peng, Bertha Leticia Rodriguez, Lixia Diao, Limo Chen, Jing Wang, Lauren A. Byers, Ying Wei, Harold A. Chapman, Mitsuo Yamauchi, Carmen Behrens, Gabriela Raso, Luisa Maren Solis Soto, Edwin Roger Parra Cuentes, Ignacio I. Wistuba, Jonathan M. Kurie, Don L. Gibbons
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/219973ddbc6547bdba9bd0531b756cc7
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spelling	oai:doaj.org-article:219973ddbc6547bdba9bd0531b756cc72021-12-02T17:19:41ZCollagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion10.1038/s41467-020-18298-82041-1723https://doaj.org/article/219973ddbc6547bdba9bd0531b756cc72020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18298-8https://doaj.org/toc/2041-1723Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion.David H. PengBertha Leticia RodriguezLixia DiaoLimo ChenJing WangLauren A. ByersYing WeiHarold A. ChapmanMitsuo YamauchiCarmen BehrensGabriela RasoLuisa Maren Solis SotoEdwin Roger Parra CuentesIgnacio I. WistubaJonathan M. KurieDon L. GibbonsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
description	Tumor extracellular matrix has been associated with cancer progression, therapy resistance and immune suppression. Here, the authors show that collagen generates resistance to PD-1/PD-L1 immunotherapy by upregulating LAIR1 expression and downstream signaling, leading to increased CD8+ T cell exhaustion.
format	article
author	David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons
author_facet	David H. Peng Bertha Leticia Rodriguez Lixia Diao Limo Chen Jing Wang Lauren A. Byers Ying Wei Harold A. Chapman Mitsuo Yamauchi Carmen Behrens Gabriela Raso Luisa Maren Solis Soto Edwin Roger Parra Cuentes Ignacio I. Wistuba Jonathan M. Kurie Don L. Gibbons
author_sort	David H. Peng
title	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_short	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_full	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_fullStr	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_full_unstemmed	Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
title_sort	collagen promotes anti-pd-1/pd-l1 resistance in cancer through lair1-dependent cd8+ t cell exhaustion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/219973ddbc6547bdba9bd0531b756cc7
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Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

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