NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.

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Auteurs principaux: Yuli He, Huayue Song, Jian Chen, Shaolin Zhu
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/21aec21fa86f4c61be72924901c3cf28
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