NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines

Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.

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Autores principales: Yuli He, Huayue Song, Jian Chen, Shaolin Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/21aec21fa86f4c61be72924901c3cf28
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spelling oai:doaj.org-article:21aec21fa86f4c61be72924901c3cf282021-12-02T13:24:33ZNiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines10.1038/s41467-020-20888-52041-1723https://doaj.org/article/21aec21fa86f4c61be72924901c3cf282021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20888-5https://doaj.org/toc/2041-1723Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.Yuli HeHuayue SongJian ChenShaolin ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuli He
Huayue Song
Jian Chen
Shaolin Zhu
NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
description Chiral benzylamines are found in many pharmacologically active molecules. Here, the authors report an enantio- and regio-selective reductive hydroarylation of N-acyl enamines with a NiH/chiral bis-imidazoline catalytic system affording a range of enantioenriched benzylamines.
format article
author Yuli He
Huayue Song
Jian Chen
Shaolin Zhu
author_facet Yuli He
Huayue Song
Jian Chen
Shaolin Zhu
author_sort Yuli He
title NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
title_short NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
title_full NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
title_fullStr NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
title_full_unstemmed NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines
title_sort nih-catalyzed asymmetric hydroarylation of n-acyl enamines to chiral benzylamines
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/21aec21fa86f4c61be72924901c3cf28
work_keys_str_mv AT yulihe nihcatalyzedasymmetrichydroarylationofnacylenaminestochiralbenzylamines
AT huayuesong nihcatalyzedasymmetrichydroarylationofnacylenaminestochiralbenzylamines
AT jianchen nihcatalyzedasymmetrichydroarylationofnacylenaminestochiralbenzylamines
AT shaolinzhu nihcatalyzedasymmetrichydroarylationofnacylenaminestochiralbenzylamines
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