Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury
In this study, deer suet fat was used as a raw material to study the effects of aqueous enzymatic extraction of deer oil on its components, followed by studies into the potential protective activity, and related molecular mechanisms of deer oil on ethanol-induced acute gastric mucosal injury in rats...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:21b05b8704b94ea5a0a223d87da0062d2021-11-16T04:56:00ZEffect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury2296-861X10.3389/fnut.2021.769463https://doaj.org/article/21b05b8704b94ea5a0a223d87da0062d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.769463/fullhttps://doaj.org/toc/2296-861XIn this study, deer suet fat was used as a raw material to study the effects of aqueous enzymatic extraction of deer oil on its components, followed by studies into the potential protective activity, and related molecular mechanisms of deer oil on ethanol-induced acute gastric mucosal injury in rats. The results show that aqueous enzymatic extraction of deer oil not only has a high extraction yield and has a small effect on the content of active ingredients. Deer oil can reduce total stomach injury. Without affecting the blood lipid level, it can reduce the oxidative stress, which is manifested by reducing the content of myeloperoxidase (MPO) and enhancing the activity level of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). It also enhances the expression of defense factors prostaglandin (E2), epidermal growth factor (EGF), and somatostatin (SS), it inhibits apoptosis evidenced by the enhanced of Bcl-2 and decreased expression of cleavage of caspase-3 and Bax. At the same time, it reduces inflammation, which is manifested by reducing the expression of IL-1β, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) gastric tissue pro-inflammatory cytokines, and enhancing the expression of anti-inflammatory factors IL-4 and IL-10, and inhibiting the mitogen-activated protein kinase/nuclear factor kappa B (MAPK/NF-κB) signaling pathway in gastric tissue.Yun-Shi XiaYun-Shi XiaYin-shi SunYin-shi SunChang LiuZhi-Man LiDuo-Duo RenDuo-Duo RenRui MuRui MuYan-Ting ZhangPan-Pan BoPan-Pan BoLi-juan ZhaoZi WangFrontiers Media S.A.articledeer oilaqueous enzymatic extractionethanolgastric mucosal injuryMAPK pathwayNF-κB pathwayNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021) |
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deer oil aqueous enzymatic extraction ethanol gastric mucosal injury MAPK pathway NF-κB pathway Nutrition. Foods and food supply TX341-641 |
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deer oil aqueous enzymatic extraction ethanol gastric mucosal injury MAPK pathway NF-κB pathway Nutrition. Foods and food supply TX341-641 Yun-Shi Xia Yun-Shi Xia Yin-shi Sun Yin-shi Sun Chang Liu Zhi-Man Li Duo-Duo Ren Duo-Duo Ren Rui Mu Rui Mu Yan-Ting Zhang Pan-Pan Bo Pan-Pan Bo Li-juan Zhao Zi Wang Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury |
| description |
In this study, deer suet fat was used as a raw material to study the effects of aqueous enzymatic extraction of deer oil on its components, followed by studies into the potential protective activity, and related molecular mechanisms of deer oil on ethanol-induced acute gastric mucosal injury in rats. The results show that aqueous enzymatic extraction of deer oil not only has a high extraction yield and has a small effect on the content of active ingredients. Deer oil can reduce total stomach injury. Without affecting the blood lipid level, it can reduce the oxidative stress, which is manifested by reducing the content of myeloperoxidase (MPO) and enhancing the activity level of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). It also enhances the expression of defense factors prostaglandin (E2), epidermal growth factor (EGF), and somatostatin (SS), it inhibits apoptosis evidenced by the enhanced of Bcl-2 and decreased expression of cleavage of caspase-3 and Bax. At the same time, it reduces inflammation, which is manifested by reducing the expression of IL-1β, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) gastric tissue pro-inflammatory cytokines, and enhancing the expression of anti-inflammatory factors IL-4 and IL-10, and inhibiting the mitogen-activated protein kinase/nuclear factor kappa B (MAPK/NF-κB) signaling pathway in gastric tissue. |
| format |
article |
| author |
Yun-Shi Xia Yun-Shi Xia Yin-shi Sun Yin-shi Sun Chang Liu Zhi-Man Li Duo-Duo Ren Duo-Duo Ren Rui Mu Rui Mu Yan-Ting Zhang Pan-Pan Bo Pan-Pan Bo Li-juan Zhao Zi Wang |
| author_facet |
Yun-Shi Xia Yun-Shi Xia Yin-shi Sun Yin-shi Sun Chang Liu Zhi-Man Li Duo-Duo Ren Duo-Duo Ren Rui Mu Rui Mu Yan-Ting Zhang Pan-Pan Bo Pan-Pan Bo Li-juan Zhao Zi Wang |
| author_sort |
Yun-Shi Xia |
| title |
Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury |
| title_short |
Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury |
| title_full |
Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury |
| title_fullStr |
Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury |
| title_full_unstemmed |
Effect of Aqueous Enzymatic Extraction of Deer Oil on Its Components and Its Protective Effect on Gastric Mucosa Injury |
| title_sort |
effect of aqueous enzymatic extraction of deer oil on its components and its protective effect on gastric mucosa injury |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/21b05b8704b94ea5a0a223d87da0062d |
| work_keys_str_mv |
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