Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion

Conformational conversion of the cellular isoform of prion protein, PrP<sup>C</sup>, into the abnormally folded, amyloidogenic isoform, PrP<sup>Sc</sup>, is an underlying pathogenic mechanism in prion diseases. The diseases manifest as sporadic, hereditary, and acquired disor...

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Autores principales: Hideyuki Hara, Suehiro Sakaguchi
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/21c6fb74577f46fdba3cfa2a3a51263b
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