Role of the activation peptide in the mechanism of protein C activation

Abstract Protein C is a natural anticoagulant activated by thrombin in a reaction accelerated by the cofactor thrombomodulin. The zymogen to protease conversion of protein C involves removal of a short activation peptide that, relative to the analogous sequence present in other vitamin K-dependent p...

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Autores principales: Bosko M. Stojanovski, Leslie A. Pelc, Enrico Di Cera
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/21d2d7669254469895a25cc38ee0ab1c
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