Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies

Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies

Abstract The natural serotypes of adeno-associated virus (AAV) or their variants, such as AAV8 and AAV5, are commonly used as vectors in the clinical programs for liver-targeted gene therapy. While AAV8 vectors are not highly efficient at targeting primary human hepatocytes, AAV3 vectors have recent...

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Autores principales: Mika Ito, Naomi Takino, Takamasa Nomura, Akihiko Kan, Shin-ichi Muramatsu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/21dbdb3102a64787821dc94a450f9501
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