SETD1A protects from senescence through regulation of the mitotic gene expression program

SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.

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Autores principales:	Ken Tajima, Satoru Matsuda, Toshifumi Yae, Benjamin J. Drapkin, Robert Morris, Myriam Boukhali, Kira Niederhoffer, Valentine Comaills, Taronish Dubash, Linda Nieman, Hongshan Guo, Neelima K. C. Magnus, Nick Dyson, Toshihiro Shioda, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/21e385ead60048f085bedca5bc235b72
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spelling	oai:doaj.org-article:21e385ead60048f085bedca5bc235b722021-12-02T14:39:18ZSETD1A protects from senescence through regulation of the mitotic gene expression program10.1038/s41467-019-10786-w2041-1723https://doaj.org/article/21e385ead60048f085bedca5bc235b722019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10786-whttps://doaj.org/toc/2041-1723SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.Ken TajimaSatoru MatsudaToshifumi YaeBenjamin J. DrapkinRobert MorrisMyriam BoukhaliKira NiederhofferValentine ComaillsTaronish DubashLinda NiemanHongshan GuoNeelima K. C. MagnusNick DysonToshihiro ShiodaWilhelm HaasDaniel A. HaberShyamala MaheswaranNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ken Tajima Satoru Matsuda Toshifumi Yae Benjamin J. Drapkin Robert Morris Myriam Boukhali Kira Niederhoffer Valentine Comaills Taronish Dubash Linda Nieman Hongshan Guo Neelima K. C. Magnus Nick Dyson Toshihiro Shioda Wilhelm Haas Daniel A. Haber Shyamala Maheswaran SETD1A protects from senescence through regulation of the mitotic gene expression program
description	SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
format	article
author	Ken Tajima Satoru Matsuda Toshifumi Yae Benjamin J. Drapkin Robert Morris Myriam Boukhali Kira Niederhoffer Valentine Comaills Taronish Dubash Linda Nieman Hongshan Guo Neelima K. C. Magnus Nick Dyson Toshihiro Shioda Wilhelm Haas Daniel A. Haber Shyamala Maheswaran
author_facet	Ken Tajima Satoru Matsuda Toshifumi Yae Benjamin J. Drapkin Robert Morris Myriam Boukhali Kira Niederhoffer Valentine Comaills Taronish Dubash Linda Nieman Hongshan Guo Neelima K. C. Magnus Nick Dyson Toshihiro Shioda Wilhelm Haas Daniel A. Haber Shyamala Maheswaran
author_sort	Ken Tajima
title	SETD1A protects from senescence through regulation of the mitotic gene expression program
title_short	SETD1A protects from senescence through regulation of the mitotic gene expression program
title_full	SETD1A protects from senescence through regulation of the mitotic gene expression program
title_fullStr	SETD1A protects from senescence through regulation of the mitotic gene expression program
title_full_unstemmed	SETD1A protects from senescence through regulation of the mitotic gene expression program
title_sort	setd1a protects from senescence through regulation of the mitotic gene expression program
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/21e385ead60048f085bedca5bc235b72
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SETD1A protects from senescence through regulation of the mitotic gene expression program

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