In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy
Abstract Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these conditions mostly relies on ursodeoxycholic acid wit...
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| Auteurs principaux: | , , , , , , |
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| Format: | article |
| Langue: | EN |
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BMC
2021
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| Accès en ligne: | https://doaj.org/article/2224e9e12283412f8afa4558224ab794 |
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