In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy

Abstract Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these conditions mostly relies on ursodeoxycholic acid wit...

Full description

Saved in:
Bibliographic Details
Main Authors: Elodie Mareux, Martine Lapalus, Amel Ben-Saad, Isabelle Callebaut, Thomas Falguières, Emmanuel Gonzales, Emmanuel Jacquemin
Format: article
Language:EN
Published: BMC 2021
Subjects:
R
Online Access:https://doaj.org/article/2224e9e12283412f8afa4558224ab794
Tags: Add Tag
No Tags, Be the first to tag this record!