Targeted Mass Spectrometry Enables Multiplexed Quantification of Immunomodulatory Proteins in Clinical Biospecimens

Immunotherapies are revolutionizing cancer care, producing durable responses and potentially cures in a subset of patients. However, response rates are low for most tumors, grade 3/4 toxicities are not uncommon, and our current understanding of tumor immunobiology is incomplete. While hundreds of im...

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Auteurs principaux:	Jeffrey R. Whiteaker, Rachel A. Lundeen, Lei Zhao, Regine M. Schoenherr, Aura Burian, Dongqing Huang, Ulianna Voytovich, Tao Wang, Jacob J. Kennedy, Richard G. Ivey, Chenwei Lin, Oscar D. Murillo, Travis D. Lorentzen, Mathangi Thiagarajan, Simona Colantonio, Tessa W. Caceres, Rhonda R. Roberts, Joseph G. Knotts, Joshua J. Reading, Jan A. Kaczmarczyk, Christopher W. Richardson, Sandra S. Garcia-Buntley, William Bocik, Stephen M. Hewitt, Karen E. Murray, Nhan Do, Mary Brophy, Stephen W. Wilz, Hongbo Yu, Samuel Ajjarapu, Emily Boja, Tara Hiltke, Henry Rodriguez, Amanda G. Paulovich
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	immunotherapy cancer correlative biomarkers mass spectrometry immuno-MRM Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/2231b7f4bf4c4dfdac9a7d21bf8f78b2
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Targeted Mass Spectrometry Enables Multiplexed Quantification of Immunomodulatory Proteins in Clinical Biospecimens

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