A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus

A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus

Currently, there are no treatments or vaccines against Epstein-Barr virus (EBV) infection. Here, Zhu et al. isolate gH/gL-specific antibodies from infected donors and identify 1D8, that substantially reduces infection levels in both, B- and epithelial cells, and reduces tumor burdens in EBV-challang...

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Autores principales: Qian-Ying Zhu, Sisi Shan, Jinfang Yu, Si-Ying Peng, Cong Sun, Yanan Zuo, Lan-Yi Zhong, Shu-Mei Yan, Xiao Zhang, Ziqing Yang, Yong-Jian Peng, Xuanling Shi, Su-Mei Cao, Xinquan Wang, Mu-Sheng Zeng, Linqi Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2239cf6967614df582f09b6994a16020
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spelling oai:doaj.org-article:2239cf6967614df582f09b6994a160202021-11-21T12:35:38ZA potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus10.1038/s41467-021-26912-62041-1723https://doaj.org/article/2239cf6967614df582f09b6994a160202021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26912-6https://doaj.org/toc/2041-1723Currently, there are no treatments or vaccines against Epstein-Barr virus (EBV) infection. Here, Zhu et al. isolate gH/gL-specific antibodies from infected donors and identify 1D8, that substantially reduces infection levels in both, B- and epithelial cells, and reduces tumor burdens in EBV-challanged humanized mice due to interferance with the gH/gL-mediated membrane fusion and binding.Qian-Ying ZhuSisi ShanJinfang YuSi-Ying PengCong SunYanan ZuoLan-Yi ZhongShu-Mei YanXiao ZhangZiqing YangYong-Jian PengXuanling ShiSu-Mei CaoXinquan WangMu-Sheng ZengLinqi ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qian-Ying Zhu
Sisi Shan
Jinfang Yu
Si-Ying Peng
Cong Sun
Yanan Zuo
Lan-Yi Zhong
Shu-Mei Yan
Xiao Zhang
Ziqing Yang
Yong-Jian Peng
Xuanling Shi
Su-Mei Cao
Xinquan Wang
Mu-Sheng Zeng
Linqi Zhang
A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
description Currently, there are no treatments or vaccines against Epstein-Barr virus (EBV) infection. Here, Zhu et al. isolate gH/gL-specific antibodies from infected donors and identify 1D8, that substantially reduces infection levels in both, B- and epithelial cells, and reduces tumor burdens in EBV-challanged humanized mice due to interferance with the gH/gL-mediated membrane fusion and binding.
format article
author Qian-Ying Zhu
Sisi Shan
Jinfang Yu
Si-Ying Peng
Cong Sun
Yanan Zuo
Lan-Yi Zhong
Shu-Mei Yan
Xiao Zhang
Ziqing Yang
Yong-Jian Peng
Xuanling Shi
Su-Mei Cao
Xinquan Wang
Mu-Sheng Zeng
Linqi Zhang
author_facet Qian-Ying Zhu
Sisi Shan
Jinfang Yu
Si-Ying Peng
Cong Sun
Yanan Zuo
Lan-Yi Zhong
Shu-Mei Yan
Xiao Zhang
Ziqing Yang
Yong-Jian Peng
Xuanling Shi
Su-Mei Cao
Xinquan Wang
Mu-Sheng Zeng
Linqi Zhang
author_sort Qian-Ying Zhu
title A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
title_short A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
title_full A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
title_fullStr A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
title_full_unstemmed A potent and protective human neutralizing antibody targeting a novel vulnerable site of Epstein-Barr virus
title_sort potent and protective human neutralizing antibody targeting a novel vulnerable site of epstein-barr virus
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2239cf6967614df582f09b6994a16020
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