Functional role of PGAM5 multimeric assemblies and their polymerization into filaments

PGAM5 is a mitochondrial protein phosphatase whose functions include regulation of mitophagy and cell death. Here, the authors use x-ray crystallography and EM to show that PGAM5 forms dodecameric rings and filaments in solution, and find that PGAM5 rings are essential for catalysis and for a struct...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karen Ruiz, Tarjani M. Thaker, Christopher Agnew, Lakshmi Miller-Vedam, Raphael Trenker, Clara Herrera, Maria Ingaramo, Daniel Toso, Adam Frost, Natalia Jura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/224769ad2a28455cbf308ca51e75d047
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:224769ad2a28455cbf308ca51e75d047
record_format	dspace
spelling	oai:doaj.org-article:224769ad2a28455cbf308ca51e75d0472021-12-02T15:35:50ZFunctional role of PGAM5 multimeric assemblies and their polymerization into filaments10.1038/s41467-019-08393-w2041-1723https://doaj.org/article/224769ad2a28455cbf308ca51e75d0472019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08393-whttps://doaj.org/toc/2041-1723PGAM5 is a mitochondrial protein phosphatase whose functions include regulation of mitophagy and cell death. Here, the authors use x-ray crystallography and EM to show that PGAM5 forms dodecameric rings and filaments in solution, and find that PGAM5 rings are essential for catalysis and for a structural effect PGAM5 has on mitochondrial membranes, independently of catalytic activity.Karen RuizTarjani M. ThakerChristopher AgnewLakshmi Miller-VedamRaphael TrenkerClara HerreraMaria IngaramoDaniel TosoAdam FrostNatalia JuraNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karen Ruiz Tarjani M. Thaker Christopher Agnew Lakshmi Miller-Vedam Raphael Trenker Clara Herrera Maria Ingaramo Daniel Toso Adam Frost Natalia Jura Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
description	PGAM5 is a mitochondrial protein phosphatase whose functions include regulation of mitophagy and cell death. Here, the authors use x-ray crystallography and EM to show that PGAM5 forms dodecameric rings and filaments in solution, and find that PGAM5 rings are essential for catalysis and for a structural effect PGAM5 has on mitochondrial membranes, independently of catalytic activity.
format	article
author	Karen Ruiz Tarjani M. Thaker Christopher Agnew Lakshmi Miller-Vedam Raphael Trenker Clara Herrera Maria Ingaramo Daniel Toso Adam Frost Natalia Jura
author_facet	Karen Ruiz Tarjani M. Thaker Christopher Agnew Lakshmi Miller-Vedam Raphael Trenker Clara Herrera Maria Ingaramo Daniel Toso Adam Frost Natalia Jura
author_sort	Karen Ruiz
title	Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
title_short	Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
title_full	Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
title_fullStr	Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
title_full_unstemmed	Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
title_sort	functional role of pgam5 multimeric assemblies and their polymerization into filaments
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/224769ad2a28455cbf308ca51e75d047
work_keys_str_mv	AT karenruiz functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT tarjanimthaker functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT christopheragnew functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT lakshmimillervedam functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT raphaeltrenker functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT claraherrera functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT mariaingaramo functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT danieltoso functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT adamfrost functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments AT nataliajura functionalroleofpgam5multimericassembliesandtheirpolymerizationintofilaments
_version_	1718386399877529600

Functional role of PGAM5 multimeric assemblies and their polymerization into filaments

Ejemplares similares