Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus

Azole antifungals inhibit fungal ergosterol biosynthesis. Here, Geißel et al. show that the fungicidal activity of azoles involves excessive synthesis of cell wall carbohydrates at defined spots along the hyphae, leading to formation of membrane invaginations and eventually rupture of the plasma mem...

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Auteurs principaux: Bernadette Geißel, Veronika Loiko, Isabel Klugherz, Zhaojun Zhu, Nikola Wagener, Oliver Kurzai, Cees A. M. J. J. van den Hondel, Johannes Wagener
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/2252e1eba4394b62b205daded5a0c215
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