Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus

Azole antifungals inhibit fungal ergosterol biosynthesis. Here, Geißel et al. show that the fungicidal activity of azoles involves excessive synthesis of cell wall carbohydrates at defined spots along the hyphae, leading to formation of membrane invaginations and eventually rupture of the plasma mem...

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Autores principales:	Bernadette Geißel, Veronika Loiko, Isabel Klugherz, Zhaojun Zhu, Nikola Wagener, Oliver Kurzai, Cees A. M. J. J. van den Hondel, Johannes Wagener
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2252e1eba4394b62b205daded5a0c215
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spelling	oai:doaj.org-article:2252e1eba4394b62b205daded5a0c2152021-12-02T16:50:10ZAzole-induced cell wall carbohydrate patches kill Aspergillus fumigatus10.1038/s41467-018-05497-72041-1723https://doaj.org/article/2252e1eba4394b62b205daded5a0c2152018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05497-7https://doaj.org/toc/2041-1723Azole antifungals inhibit fungal ergosterol biosynthesis. Here, Geißel et al. show that the fungicidal activity of azoles involves excessive synthesis of cell wall carbohydrates at defined spots along the hyphae, leading to formation of membrane invaginations and eventually rupture of the plasma membrane.Bernadette GeißelVeronika LoikoIsabel KlugherzZhaojun ZhuNikola WagenerOliver KurzaiCees A. M. J. J. van den HondelJohannes WagenerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernadette Geißel Veronika Loiko Isabel Klugherz Zhaojun Zhu Nikola Wagener Oliver Kurzai Cees A. M. J. J. van den Hondel Johannes Wagener Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
description	Azole antifungals inhibit fungal ergosterol biosynthesis. Here, Geißel et al. show that the fungicidal activity of azoles involves excessive synthesis of cell wall carbohydrates at defined spots along the hyphae, leading to formation of membrane invaginations and eventually rupture of the plasma membrane.
format	article
author	Bernadette Geißel Veronika Loiko Isabel Klugherz Zhaojun Zhu Nikola Wagener Oliver Kurzai Cees A. M. J. J. van den Hondel Johannes Wagener
author_facet	Bernadette Geißel Veronika Loiko Isabel Klugherz Zhaojun Zhu Nikola Wagener Oliver Kurzai Cees A. M. J. J. van den Hondel Johannes Wagener
author_sort	Bernadette Geißel
title	Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
title_short	Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
title_full	Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
title_fullStr	Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
title_full_unstemmed	Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus
title_sort	azole-induced cell wall carbohydrate patches kill aspergillus fumigatus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2252e1eba4394b62b205daded5a0c215
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Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus

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