Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

Summary: Upregulation and stabilization of Foxp3 expression in Tregs are essential for regulating Treg function and immune homeostasis. In this study, gp96 immunization showed obvious therapeutic effects in a Lyn–/– mouse model of systemic lupus erythematosus. Moreover, gp96 alleviated the initiatio...

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Autores principales: Yuxiu Xu, Erlong Liu, Xialin Xie, Jiuru Wang, Huaguo Zheng, Ying Ju, Lizhao Chen, Changfei Li, Xuyu Zhou, Zihai Li, Xin Li, Songdong Meng
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/2255ee2f5d894a2ba1e046fa83a0f70a
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