Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.

The transmission of genomic information from coding sequence to protein structure during protein synthesis is subject to stochastic errors. To analyze transmission limits in the presence of spurious errors, Shannon's noisy channel theorem is applied to a communication channel between amino acid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Andreas Martin Lisewski
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/22e56c9f285348d6b6f2b56b1322e013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:22e56c9f285348d6b6f2b56b1322e013
record_format	dspace
spelling	oai:doaj.org-article:22e56c9f285348d6b6f2b56b1322e0132021-11-25T06:18:46ZRandom amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.1932-620310.1371/journal.pone.0003110https://doaj.org/article/22e56c9f285348d6b6f2b56b1322e0132008-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18769673/?tool=EBIhttps://doaj.org/toc/1932-6203The transmission of genomic information from coding sequence to protein structure during protein synthesis is subject to stochastic errors. To analyze transmission limits in the presence of spurious errors, Shannon's noisy channel theorem is applied to a communication channel between amino acid sequences and their structures established from a large-scale statistical analysis of protein atomic coordinates. While Shannon's theorem confirms that in close to native conformations information is transmitted with limited error probability, additional random errors in sequence (amino acid substitutions) and in structure (structural defects) trigger a decrease in communication capacity toward a Shannon limit at 0.010 bits per amino acid symbol at which communication breaks down. In several controls, simulated error rates above a critical threshold and models of unfolded structures always produce capacities below this limiting value. Thus an essential biological system can be realistically modeled as a digital communication channel that is (a) sensitive to random errors and (b) restricted by a Shannon error limit. This forms a novel basis for predictions consistent with observed rates of defective ribosomal products during protein synthesis, and with the estimated excess of mutual information in protein contact potentials.Andreas Martin LisewskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 9, p e3110 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andreas Martin Lisewski Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.
description	The transmission of genomic information from coding sequence to protein structure during protein synthesis is subject to stochastic errors. To analyze transmission limits in the presence of spurious errors, Shannon's noisy channel theorem is applied to a communication channel between amino acid sequences and their structures established from a large-scale statistical analysis of protein atomic coordinates. While Shannon's theorem confirms that in close to native conformations information is transmitted with limited error probability, additional random errors in sequence (amino acid substitutions) and in structure (structural defects) trigger a decrease in communication capacity toward a Shannon limit at 0.010 bits per amino acid symbol at which communication breaks down. In several controls, simulated error rates above a critical threshold and models of unfolded structures always produce capacities below this limiting value. Thus an essential biological system can be realistically modeled as a digital communication channel that is (a) sensitive to random errors and (b) restricted by a Shannon error limit. This forms a novel basis for predictions consistent with observed rates of defective ribosomal products during protein synthesis, and with the estimated excess of mutual information in protein contact potentials.
format	article
author	Andreas Martin Lisewski
author_facet	Andreas Martin Lisewski
author_sort	Andreas Martin Lisewski
title	Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.
title_short	Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.
title_full	Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.
title_fullStr	Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.
title_full_unstemmed	Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.
title_sort	random amino acid mutations and protein misfolding lead to shannon limit in sequence-structure communication.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/22e56c9f285348d6b6f2b56b1322e013
work_keys_str_mv	AT andreasmartinlisewski randomaminoacidmutationsandproteinmisfoldingleadtoshannonlimitinsequencestructurecommunication
_version_	1718413911514939392

Random amino acid mutations and protein misfolding lead to Shannon limit in sequence-structure communication.

Ejemplares similares