Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kina...

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Autores principales:	Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann, Martin S. Denzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/239d229d7b824a359ee93d56ac13b688
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spelling	oai:doaj.org-article:239d229d7b824a359ee93d56ac13b6882021-12-02T15:51:06ZProtein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-110.1038/s41467-021-22320-y2041-1723https://doaj.org/article/239d229d7b824a359ee93d56ac13b6882021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22320-yhttps://doaj.org/toc/2041-1723The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kinase A (PKA)-mediated phosphorylation.Sabine RuegenbergFelix A. M. C. MayrIlian AtanassovUlrich BaumannMartin S. DenzelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sabine Ruegenberg Felix A. M. C. Mayr Ilian Atanassov Ulrich Baumann Martin S. Denzel Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
description	The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kinase A (PKA)-mediated phosphorylation.
format	article
author	Sabine Ruegenberg Felix A. M. C. Mayr Ilian Atanassov Ulrich Baumann Martin S. Denzel
author_facet	Sabine Ruegenberg Felix A. M. C. Mayr Ilian Atanassov Ulrich Baumann Martin S. Denzel
author_sort	Sabine Ruegenberg
title	Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
title_short	Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
title_full	Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
title_fullStr	Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
title_full_unstemmed	Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
title_sort	protein kinase a controls the hexosamine pathway by tuning the feedback inhibition of gfat-1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/239d229d7b824a359ee93d56ac13b688
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Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

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