Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1

The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kina...

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Autores principales: Sabine Ruegenberg, Felix A. M. C. Mayr, Ilian Atanassov, Ulrich Baumann, Martin S. Denzel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/239d229d7b824a359ee93d56ac13b688
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