Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome

Nucleosome organization has been suggested to affect local mutation rates in the genome. Here, the authors analyse data on >300,000 human de novo mutations and high-resolution nucleosome maps and provide evidence that nucleosome positioning stability modulates germline mutation rate variation acr...

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Bibliographic Details
Main Authors: Cai Li, Nicholas M. Luscombe
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/23ca1f57c02745bc969e2879df4387b6
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