Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome

Nucleosome organization has been suggested to affect local mutation rates in the genome. Here, the authors analyse data on >300,000 human de novo mutations and high-resolution nucleosome maps and provide evidence that nucleosome positioning stability modulates germline mutation rate variation acr...

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Autores principales:	Cai Li, Nicholas M. Luscombe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23ca1f57c02745bc969e2879df4387b6
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spelling	oai:doaj.org-article:23ca1f57c02745bc969e2879df4387b62021-12-02T14:40:39ZNucleosome positioning stability is a modulator of germline mutation rate variation across the human genome10.1038/s41467-020-15185-02041-1723https://doaj.org/article/23ca1f57c02745bc969e2879df4387b62020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15185-0https://doaj.org/toc/2041-1723Nucleosome organization has been suggested to affect local mutation rates in the genome. Here, the authors analyse data on >300,000 human de novo mutations and high-resolution nucleosome maps and provide evidence that nucleosome positioning stability modulates germline mutation rate variation across the human genome.Cai LiNicholas M. LuscombeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cai Li Nicholas M. Luscombe Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
description	Nucleosome organization has been suggested to affect local mutation rates in the genome. Here, the authors analyse data on >300,000 human de novo mutations and high-resolution nucleosome maps and provide evidence that nucleosome positioning stability modulates germline mutation rate variation across the human genome.
format	article
author	Cai Li Nicholas M. Luscombe
author_facet	Cai Li Nicholas M. Luscombe
author_sort	Cai Li
title	Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
title_short	Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
title_full	Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
title_fullStr	Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
title_full_unstemmed	Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
title_sort	nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/23ca1f57c02745bc969e2879df4387b6
work_keys_str_mv	AT caili nucleosomepositioningstabilityisamodulatorofgermlinemutationratevariationacrossthehumangenome AT nicholasmluscombe nucleosomepositioningstabilityisamodulatorofgermlinemutationratevariationacrossthehumangenome
_version_	1718390161678532608

Nucleosome positioning stability is a modulator of germline mutation rate variation across the human genome

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