Circadian clock disruption by selective removal of endogenous carbon monoxide

Abstract Circadian rhythms are regulated by transcription-translation feedback loops (TTFL) of clock genes. Previous studies have demonstrated that core transcriptional factors, NPAS2 and CLOCK, in the TTFL can reversibly bind carbon monoxide (CO) in vitro. However, little is known about whether end...

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Bibliographic Details
Main Authors: Saika Minegishi, Ikuko Sagami, Shigeru Negi, Koji Kano, Hiroaki Kitagishi
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
R
Q
Online Access:https://doaj.org/article/24186bf1afc04da39932da7b83b32754
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