PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

Abstract The Published Kinase Inhibitor Set (PKIS) is a publicly-available chemogenomic library distributed to more than 300 laboratories by GlaxoSmithKline (GSK) between 2011 and 2015 and by SGC-UNC from 2015 to 2017. Screening this library of well-annotated, published kinase inhibitors has yielded...

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Auteurs principaux: Tigist Y. Tamir, David H. Drewry, Carrow Wells, M. Ben Major, Alison D. Axtman
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/2427271ceabc4a4d9e480023fca08c5f
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