PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is dependent on its phosphatase activity through the...

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Autores principales: Swapnil Rohidas Shinde, Subbareddy Maddika
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2446edc45d3d4c859ad987930667c45a
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