PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is dependent on its phosphatase activity through the...

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Autores principales:	Swapnil Rohidas Shinde, Subbareddy Maddika
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2446edc45d3d4c859ad987930667c45a
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spelling	oai:doaj.org-article:2446edc45d3d4c859ad987930667c45a2021-12-02T15:35:43ZPTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab710.1038/ncomms106892041-1723https://doaj.org/article/2446edc45d3d4c859ad987930667c45a2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10689https://doaj.org/toc/2041-1723Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is dependent on its phosphatase activity through the direct post-translational modification of Rab7.Swapnil Rohidas ShindeSubbareddy MaddikaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swapnil Rohidas Shinde Subbareddy Maddika PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
description	Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is dependent on its phosphatase activity through the direct post-translational modification of Rab7.
format	article
author	Swapnil Rohidas Shinde Subbareddy Maddika
author_facet	Swapnil Rohidas Shinde Subbareddy Maddika
author_sort	Swapnil Rohidas Shinde
title	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
title_short	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
title_full	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
title_fullStr	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
title_full_unstemmed	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
title_sort	pten modulates egfr late endocytic trafficking and degradation by dephosphorylating rab7
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2446edc45d3d4c859ad987930667c45a
work_keys_str_mv	AT swapnilrohidasshinde ptenmodulatesegfrlateendocytictraffickinganddegradationbydephosphorylatingrab7 AT subbareddymaddika ptenmodulatesegfrlateendocytictraffickinganddegradationbydephosphorylatingrab7
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PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

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