Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the crystal structure of 3I14 Fab in complex with H3, H6,...

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Autores principales:	Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A. Marasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/246479680d0d43448f6a2d4b305f320c
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spelling	oai:doaj.org-article:246479680d0d43448f6a2d4b305f320c2021-12-02T13:24:33ZUnique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses10.1038/s41467-020-20879-62041-1723https://doaj.org/article/246479680d0d43448f6a2d4b305f320c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20879-6https://doaj.org/toc/2041-1723Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the crystal structure of 3I14 Fab in complex with H3, H6, and H10.Wayne D. HarshbargerDerrick DemingGordon J. LockbaumNattapol AttatippaholkunMaliwan KamkaewShurong HouMohan SomasundaranJennifer P. WangRobert W. FinbergQuan Karen ZhuCelia A. SchifferWayne A. MarascoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wayne D. Harshbarger Derrick Deming Gordon J. Lockbaum Nattapol Attatippaholkun Maliwan Kamkaew Shurong Hou Mohan Somasundaran Jennifer P. Wang Robert W. Finberg Quan Karen Zhu Celia A. Schiffer Wayne A. Marasco Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses
description	Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the crystal structure of 3I14 Fab in complex with H3, H6, and H10.
format	article
author	Wayne D. Harshbarger Derrick Deming Gordon J. Lockbaum Nattapol Attatippaholkun Maliwan Kamkaew Shurong Hou Mohan Somasundaran Jennifer P. Wang Robert W. Finberg Quan Karen Zhu Celia A. Schiffer Wayne A. Marasco
author_facet	Wayne D. Harshbarger Derrick Deming Gordon J. Lockbaum Nattapol Attatippaholkun Maliwan Kamkaew Shurong Hou Mohan Somasundaran Jennifer P. Wang Robert W. Finberg Quan Karen Zhu Celia A. Schiffer Wayne A. Marasco
author_sort	Wayne D. Harshbarger
title	Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses
title_short	Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses
title_full	Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses
title_fullStr	Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses
title_full_unstemmed	Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses
title_sort	unique structural solution from a v h 3-30 antibody targeting the hemagglutinin stem of influenza a viruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/246479680d0d43448f6a2d4b305f320c
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Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses

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