Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

Fibroblast hyper-activation and proliferation is a major feature in arthritis, yet scarcely addressed for anti-arthritic therapies. Here, the authors show that activation of the MC1 receptor induces fibroblast senescence associated with a reparative phenotype, ultimately regulating experimental infl...

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Autores principales: Trinidad Montero-Melendez, Ai Nagano, Claude Chelala, Andrew Filer, Christopher D. Buckley, Mauro Perretti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/246ccaf422484b3fb4762cf7e38547f9
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spelling oai:doaj.org-article:246ccaf422484b3fb4762cf7e38547f92021-12-02T17:31:39ZTherapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis10.1038/s41467-020-14421-x2041-1723https://doaj.org/article/246ccaf422484b3fb4762cf7e38547f92020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14421-xhttps://doaj.org/toc/2041-1723Fibroblast hyper-activation and proliferation is a major feature in arthritis, yet scarcely addressed for anti-arthritic therapies. Here, the authors show that activation of the MC1 receptor induces fibroblast senescence associated with a reparative phenotype, ultimately regulating experimental inflammatory arthritis.Trinidad Montero-MelendezAi NaganoClaude ChelalaAndrew FilerChristopher D. BuckleyMauro PerrettiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Trinidad Montero-Melendez
Ai Nagano
Claude Chelala
Andrew Filer
Christopher D. Buckley
Mauro Perretti
Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
description Fibroblast hyper-activation and proliferation is a major feature in arthritis, yet scarcely addressed for anti-arthritic therapies. Here, the authors show that activation of the MC1 receptor induces fibroblast senescence associated with a reparative phenotype, ultimately regulating experimental inflammatory arthritis.
format article
author Trinidad Montero-Melendez
Ai Nagano
Claude Chelala
Andrew Filer
Christopher D. Buckley
Mauro Perretti
author_facet Trinidad Montero-Melendez
Ai Nagano
Claude Chelala
Andrew Filer
Christopher D. Buckley
Mauro Perretti
author_sort Trinidad Montero-Melendez
title Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
title_short Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
title_full Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
title_fullStr Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
title_full_unstemmed Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
title_sort therapeutic senescence via gpcr activation in synovial fibroblasts facilitates resolution of arthritis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/246ccaf422484b3fb4762cf7e38547f9
work_keys_str_mv AT trinidadmonteromelendez therapeuticsenescenceviagpcractivationinsynovialfibroblastsfacilitatesresolutionofarthritis
AT ainagano therapeuticsenescenceviagpcractivationinsynovialfibroblastsfacilitatesresolutionofarthritis
AT claudechelala therapeuticsenescenceviagpcractivationinsynovialfibroblastsfacilitatesresolutionofarthritis
AT andrewfiler therapeuticsenescenceviagpcractivationinsynovialfibroblastsfacilitatesresolutionofarthritis
AT christopherdbuckley therapeuticsenescenceviagpcractivationinsynovialfibroblastsfacilitatesresolutionofarthritis
AT mauroperretti therapeuticsenescenceviagpcractivationinsynovialfibroblastsfacilitatesresolutionofarthritis
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