Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington’s disease

Abstract PGC-1α is a versatile inducer of mitochondrial biogenesis and responsive to the changing energy demands of the cell. As mitochondrial ATP production requires proteins that derive from translation products of cytosolic ribosomes, we asked whether PGC-1α directly takes part in ribosomal bioge...

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Main Authors: Sarah Jesse, Hanna Bayer, Marius C. Alupei, Martina Zügel, Medhanie Mulaw, Francesca Tuorto, Silke Malmsheimer, Karmveer Singh, Jürgen Steinacker, Uwe Schumann, Albert C. Ludolph, Karin Scharffetter-Kochanek, Anke Witting, Patrick Weydt, Sebastian Iben
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/2478132ea7814397b8b16d705aad350d
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https://doaj.org/article/2478132ea7814397b8b16d705aad350d

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