Cellular senescence mediates fibrotic pulmonary disease

Cellular senescence mediates fibrotic pulmonary disease

Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for trea...

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Main Authors: Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamara Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland, Daniel J. Tschumperlin, Hirohito Kita, Nathan K. LeBrasseur
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/24b84bad3904485caad4533a2d6fd946
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https://doaj.org/article/24b84bad3904485caad4533a2d6fd946

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