Cellular senescence mediates fibrotic pulmonary disease

Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for trea...

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Autores principales:	Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamara Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland, Daniel J. Tschumperlin, Hirohito Kita, Nathan K. LeBrasseur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24b84bad3904485caad4533a2d6fd946
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spelling	oai:doaj.org-article:24b84bad3904485caad4533a2d6fd9462021-12-02T17:06:30ZCellular senescence mediates fibrotic pulmonary disease10.1038/ncomms145322041-1723https://doaj.org/article/24b84bad3904485caad4533a2d6fd9462017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14532https://doaj.org/toc/2041-1723Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for treatment of human IPF.Marissa J. SchaferThomas A. WhiteKoji IijimaAndrew J. HaakGiovanni LigrestiElizabeth J. AtkinsonAnn L. ObergJodie BirchHanna SalmonowiczYi ZhuDaniel L. MazulaRobert W. BrooksHeike Fuhrmann-StroissniggTamar PirtskhalavaY. S. PrakashTamara TchkoniaPaul D. RobbinsMarie Christine AubryJoão F. PassosJames L. KirklandDaniel J. TschumperlinHirohito KitaNathan K. LeBrasseurNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marissa J. Schafer Thomas A. White Koji Iijima Andrew J. Haak Giovanni Ligresti Elizabeth J. Atkinson Ann L. Oberg Jodie Birch Hanna Salmonowicz Yi Zhu Daniel L. Mazula Robert W. Brooks Heike Fuhrmann-Stroissnigg Tamar Pirtskhalava Y. S. Prakash Tamara Tchkonia Paul D. Robbins Marie Christine Aubry João F. Passos James L. Kirkland Daniel J. Tschumperlin Hirohito Kita Nathan K. LeBrasseur Cellular senescence mediates fibrotic pulmonary disease
description	Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for treatment of human IPF.
format	article
author	Marissa J. Schafer Thomas A. White Koji Iijima Andrew J. Haak Giovanni Ligresti Elizabeth J. Atkinson Ann L. Oberg Jodie Birch Hanna Salmonowicz Yi Zhu Daniel L. Mazula Robert W. Brooks Heike Fuhrmann-Stroissnigg Tamar Pirtskhalava Y. S. Prakash Tamara Tchkonia Paul D. Robbins Marie Christine Aubry João F. Passos James L. Kirkland Daniel J. Tschumperlin Hirohito Kita Nathan K. LeBrasseur
author_facet	Marissa J. Schafer Thomas A. White Koji Iijima Andrew J. Haak Giovanni Ligresti Elizabeth J. Atkinson Ann L. Oberg Jodie Birch Hanna Salmonowicz Yi Zhu Daniel L. Mazula Robert W. Brooks Heike Fuhrmann-Stroissnigg Tamar Pirtskhalava Y. S. Prakash Tamara Tchkonia Paul D. Robbins Marie Christine Aubry João F. Passos James L. Kirkland Daniel J. Tschumperlin Hirohito Kita Nathan K. LeBrasseur
author_sort	Marissa J. Schafer
title	Cellular senescence mediates fibrotic pulmonary disease
title_short	Cellular senescence mediates fibrotic pulmonary disease
title_full	Cellular senescence mediates fibrotic pulmonary disease
title_fullStr	Cellular senescence mediates fibrotic pulmonary disease
title_full_unstemmed	Cellular senescence mediates fibrotic pulmonary disease
title_sort	cellular senescence mediates fibrotic pulmonary disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/24b84bad3904485caad4533a2d6fd946
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Cellular senescence mediates fibrotic pulmonary disease

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