Cellular senescence mediates fibrotic pulmonary disease
Removal of senescent cells rejuvenates lungs of aged mice. Here the authors show that elimination of senescent cells using either genetic or pharmacological means improves lung function and physical health in a mouse model of idiopathic pulmonary fibrosis (IPF), suggesting potential therapy for trea...
Guardado en:
Autores principales: | Marissa J. Schafer, Thomas A. White, Koji Iijima, Andrew J. Haak, Giovanni Ligresti, Elizabeth J. Atkinson, Ann L. Oberg, Jodie Birch, Hanna Salmonowicz, Yi Zhu, Daniel L. Mazula, Robert W. Brooks, Heike Fuhrmann-Stroissnigg, Tamar Pirtskhalava, Y. S. Prakash, Tamara Tchkonia, Paul D. Robbins, Marie Christine Aubry, João F. Passos, James L. Kirkland, Daniel J. Tschumperlin, Hirohito Kita, Nathan K. LeBrasseur |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/24b84bad3904485caad4533a2d6fd946 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Molecular programs of fibrotic change in aging human lung
por: Seoyeon Lee, et al.
Publicado: (2021) -
Elucidating the fundamental fibrotic processes driving abdominal adhesion formation
por: Deshka S. Foster, et al.
Publicado: (2020) -
Hemodialysis exacerbates proteolytic imbalance and pro-fibrotic platelet dysfunction
por: Aaron J. Velasquez-Mao, et al.
Publicado: (2021) -
Myofibroblasts in Normal and Fibrotic Liver in Different Animal Species
por: Vladimir Kukolj
Publicado: (2014) -
Adiponectin is an endogenous anti-fibrotic mediator and therapeutic target
por: Roberta G. Marangoni, et al.
Publicado: (2017)