Early Myeloid Derived Suppressor Cells (eMDSCs) Are Associated With High Donor Myeloid Chimerism Following Haploidentical HSCT for Sickle Cell Disease

Early Myeloid Derived Suppressor Cells (eMDSCs) Are Associated With High Donor Myeloid Chimerism Following Haploidentical HSCT for Sickle Cell Disease

Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a widely available curative option for patients with sickle cell disease (SCD). Our original non-myeloablative haplo-HSCT trial employing post-transplant (PT) cyclophosphamide had a low incidence of GVHD but had high rejection ra...

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Bibliographic Details
Main Authors: Deepali K. Bhat, Purevdorj B. Olkhanud, Arunakumar Gangaplara, Fayaz Seifuddin, Mehdi Pirooznia, Angélique Biancotto, Giovanna Fantoni, Corinne Pittman, Berline Francis, Pradeep K. Dagur, Ankit Saxena, J. Philip McCoy, Ruth M. Pfeiffer, Courtney D. Fitzhugh
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
donor myeloid chimerism
haploidentical HSCT
Tregs
IL-10
sickle cell disease
early myeloid derived suppressor cells
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/24e70ed7cf154c4e8c2147f41d584da8
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https://doaj.org/article/24e70ed7cf154c4e8c2147f41d584da8

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