A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2‐mediated epigenetic modulation in esophageal squamous cell carcinoma

A methyltransferase‐like 14/miR‐99a‐5p/tribble 2 positive feedback circuit promotes cancer stem cell persistence and radioresistance via histone deacetylase 2‐mediated epigenetic modulation in esophageal squamous cell carcinoma

Abstract Background Esophageal squamous cell carcinoma (ESCC) is a highly aggressive and treatment‐resistant tumor. The biological implications and molecular mechanism of cancer stem‐like cells (CSCs) in ESCC, which contribute to therapeutic resistance such as radioresistance, remain elusive. Method...

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Bibliographic Details
Main Authors: Zhenchuan Liu, Kaiqing Wu, Shaorui Gu, Wenli Wang, Shiliang Xie, Tiancheng Lu, Lei Li, Chenglai Dong, Xishi Wang, Yongxin Zhou
Format: article
Language:EN
Published: Wiley 2021
Subjects:
cancer stem‐like cells
esophageal squamous cell carcinoma
positive feedback loop
radioresistance
Medicine (General)
R5-920
Online Access:https://doaj.org/article/2503bc6e99a14e1f92f41f05e9c1cdb3
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https://doaj.org/article/2503bc6e99a14e1f92f41f05e9c1cdb3

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