Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.

Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.

Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single deletion of several genes essential for autophagy (ATG5...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Alice G Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Mariño, Rafal Koziel, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
Sujets:
Genetics
QH426-470
Accès en ligne:https://doaj.org/article/2513812671d248ae85a0d77c88148d65
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/2513812671d248ae85a0d77c88148d65

Documents similaires